Endocrine Abstracts

Objective: Transphenoidal hypophysectomy is currently the primary treatment for patients with acromegaly. Advances in medical and radiotherapy treatment options have resulted in uncertainty whether surgery should remain the treatment of choice for all acromegalics. The surgical cure rate for acromegaly is variable and there is a need to accurately counsel patients regarding the likelihood of successful surgical cure. We examined how lateral tumour extension into the cavernous ...

Osteoporosis and associated fractures are the most common and debilitating complication of glucocorticoid use. The use of alternative anti-inflammatory agents without the catabolic and deleterious skeletal side-effects of glucocorticoids is needed. Dehydroepiandrosterone (DHEA) may have immunomodulatory as well as positive effects on bone. To further our understanding of the mechanisms of action of DHEA, as a steroid-sparing agent, we investigated and compared the effects of D...